CONTENTS
СОДЕРЖАНИЕ
RUSSIAN JOURNAL OF CARDIOLOGY, 2015, 8 (124)
THE NEW EUROPEAN GUIDELINES ON NON-CARDIAC SURGERY: CARDIOVASCULAR ASSESSMENT AND MANAGEMENT — THE MODERN TRADITIONAL SONGS ABOUT THE MAIN?
Duplyakov D. V.
Russ J Cardiol 2015, 8 (124): 4-5
CLINICAL MEDICINE NEWS
Clinical medicine updates: a review of international news
Russ J Cardiol 2015, 8 (124): 6
CLINICAL GUIDELINES
2014 ESC/ESA GUIDELINES ON NON-CARDIAC SURGERY: CARDIOVASCULAR ASSESSMENT
AND MANAGEMENT
The Joint Task Force on non-cardiac surgery: cardiovascular assessment and management of the European Society of Cardiology (ESC) and the European Society of Anaesthesiology (ESA)
Russ J Cardiol 2015, 8 (124): 7–66
http://dx.doi.org/10.15829/1560-4071-2015-08-7-66
Key words: Guidelines, Non-cardiac surgery, Pre-operative cardiac risk assessment, Pre-operative cardiac testing, Pre-operative coronary artery revascularization, Perioperative cardiac management, Anti-thrombotic therapy, Beta-blockers, Valvular disease, Arrhythmias, Heart failure, Renal disease, Pulmonary disease, Cerebrovascular disease, Anaesthesiology, Post-operative cardiac surveillance.
2014 ESC GUIDELINES ON THE DIAGNOSIS AND MANAGEMENT OF ACUTE PULMONARY EMBOLISM
The Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC)
Russ J Cardiol 2015, 8 (124): 67–110
http://dx.doi.org/10.15829/1560-4071-2015-08-67-110
Key words: Guidelines, Pulmonary embolism, Venousthrombosis, Shock, Hypotension, Chest pain, Dyspnoea, Heart failure, Diagnosis, Treatment–Anticoagulation, Thrombolysis.
CLINIC AND PHARMACOTHERAPY
RANDOMIZED COMPARISON OF TWO APPROACHES TO WARFARIN DOSAGE IN CARDIOVASCULAR HOSPITAL SECTION
Mishchenko L. N.1, Averkov O. V.2,3, Gordeev I. G.1, Tyulkina E. E.2,3, Pavlikova E. P.2,3, Levchuk N. N.3, Pletnikova I. G.3
Abstract
Aim. To compare two approaches to warfarin dosage formulation: the standard and with the clinical algorithm.
Material and methods. As an approach to warfarin dosage, we have used the method that included clinical properties of the patients. Into the group of the studied approach (intervention group), we randomized 31 person, into the standard approach group (controls) — 29 persons with a variety of indications for vitamin K antagonists treatment. Target diapason of International Normalized Ratio (INR) for all the patients was 2,0 to 3,0.
Results. A stable target INR in both groups was reached during hospitalization just in a small part of the patients: 19,4% in intervention group and 17,2% in controls. The patients from intervention group reached stable INR by 6,8 days in average, that is almost two times faster than controls, who had their target INR by 12,4 day in average (p<0,05). Part of the INR values higher than 4,0 in intervention group was 3,6%, in control group — 18,2% (p<0,05). Thromboembolic events (strokes, pulmonary embolism repeats) has not developed in both groups. There was one bleeding episode in each of the groups.
Conclusion. Opportunities for targeting INR, not dependent on dosing regimen, are quite restricted in inpatient settings. The patients having reached target INR, usage of clinical algorithm of warfarin dosage helped to achieve these values much faster than in standard approach. Prevalence of excessive hypocoagulation while using the algorithm was lesser than in standard group.
Russ J Cardiol 2015, 8 (124): 111–122
http://dx.doi.org/10.15829/1560-4071-2015-08-111-122
Key words: warfarin, warfain dose selection, INR, stable INR, clinical algorithm, standard approach, hypocoagulation, novel anticoagulants.
1RNRMU n. a. N. I. Pirogov, Moscow; 2PFUR, Moscow; 3CCH №15 n. a. O. M. Filatov, Moscow, Russia.
