CONTENTS
СОДЕРЖАНИЕ
Address to the readers
Russ J Cardiol 2014, 1 (105): 5
CLINICAL MEDICINE NEWS
Clinical medicine updates: a review of international news
Russ J Cardiol 2014, 1 (105): 6
CLINICAL GUIDELINES
2013 ESH/ESC GUIDELINES FOR THE MANAGEMENT OF ARTERIAL HYPERTENSION
The Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)
Russ J Cardiol 2014, 1 (105): 7-94
ORIGINAL ARTICLES
VASCULAR AND CARDIAC REMODELLING AND COMBINATION THERAPY OF ARTERIAL HYPERTENSION IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Shpagina L. A.1, Shpagin I. S.1, Pospelova T. I.1, Gerasimenko O. N.1,2, Sukhaterina N. A.1,2, Alicheva Ya.M.1,2
Abstract
Aim. To assess cardiac and vascular structure and function, blood flow parameters, endothelial dysfunction, and cytokine status in patients with arterial hypertension (AH) and chronic obstructive pulmonary disease (COPD), who were administered combination Co-renitec therapy.
Material and methods.The study included 37 patients with AH and COPD, who underwent laboratory, functional, and ultrasound examination.
Results.During the 6-month combination Co-renitec therapy, the parameters of clinical status, circadian blood pressure profile, and endothelial, vascular, and cardiac structure and function were assessed in patients with AH and COPD.
Conclusion. The combination Co-renitec therapy was associated with normalised blood pressure levels, improved clinical and hemodynamic status, cardiac and vascular structure and function, and blood flow and microcirculation, as well as with reduced levels of the markers of endothelial dysfunction and systemic inflammation.
Russ J Cardiol 2014, 1 (105): 95-100
Key words: arterial hypertension, chronic obstructive pulmonary disease, cardiac and vascular remodelling, endothelial dysfunction, systemic inflammation, therapy effectiveness.
1Novosibirsk State Medical University, Department of Hospital Therapy and Medical Rehabilitation; 2City Clinical Hospital No. 2, Novosibirsk, Russia.
NEW APPROACH TOWARDS THE INTEGRAL ASSESSMENT OF CARDIOVASCULAR STATUS IN PATIENTS WITH ARTERIAL HYPERTENSION
Gurfinkel Yu.I.1, At’kov O. Yu.2, Sasonko M. L.1, Sarimov R. M.1,3
Abstract
Aim. To assess the potential of the integral assessment of cardiovascular system status in patients with arterial hypertension (AH), based on the evaluation of the parameters of microcirculation (non-invasive digital capillaroscopy) and macrocirculation (pulse wave velocity (PWV) and endothelial function).
Material and methods. The study included 188 people aged 40 years and older: 32 patients with systolic blood pressure (BP) levels 120–139 mm Hg (“PreAH” group), 36 patients with Stage 1–2 AH (“AH” group), and 85 AH patients who achieved target BP levels due to antihypertensive therapy (“Treated AH” group). The control group included 35 healthy volunteers, without any signs or symptoms of cardiovascular disease (“Healthy” group). All participants underwent clinical and laboratory examination, including office BP measurement, 24-hour BP monitoring, and echocardiography, the assessment of nailfold microcirculation, pulse wave velocity, endothelial function, as well as the measurement of BP and heart rate.
Results. There was an increase in remodelling coefficient (Cv/a) in the groups “PreAH”, “AH”, and “Treated AH”, compared to the “Healthy” group. PWV levels were significantly higher in “PreAH” and “Treated AH” groups than in the “Healthy” group. Based on micro- and macrocirculation parameters assessed, the integral index of cardiovascular status was calculated. The values of this index were significantly higher in the “AH” group. Effective antihypertensive treatment was associated with a reduction in these values.
Conclusion. Based on the assessment of a range of micro- and macrocirculation parameters in AH patients, the integral index of cardiovascular status had been developed. This index satisfactorily reflects the dynamics of micro- and macrocirculation in treated AH and, therefore, can be used as an indicator of effective antihypertensive therapy. The complex assessment of macro- and microcirculation provides an opportunity for early AH detection.
Russ J Cardiol 2014, 1 (105): 101-106
Key words: capillaroscopy, pulse wave velocity, endothelial function, integral index, prehypertension, arterial hypertension.
1Clinical Research Centre, Russian Railways, Moscow; 2N.I. Pirogov Russian National Medical Research University, Moscow; 3A.M. Prokhorov Institute of General Physics, Russian Academy of Sciences, Moscow, Russia.
LITERATURE REVIEWS
WHETHER CONTROL OF THE HEAT RATE IN THE TREATMENT OF HYPERTENSION?
Nedogoda S . V.
In this literature review indicates the importance of monitoring the heart rate in the selection and prescription of adequate antihypertensive therapy.
Russ J Cardiol 2014, 1 (105): 107-110
Key words: heart rate, blood pressure.
Volgograd State Medical University, Volgograd, Russia.